| abstract |
Indane dimer compounds of general formula 5, 6 or 9 and their pharmaceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or antiinflammatory activity are described, wherein in formulae 5 and 9, R<SP>1</SP> and R<SP>3</SP> to R<SP>15</SP>, and in formula 6, R<SP>1</SP>, R<SP>2</SP> and R<SP>4</SP> to R<SP>15</SP>, are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate. nitrite, nitroso groups, nitrile, heterocyclic groups containing one or more heteroatoms selected from N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 carbon atoms which may be saturated or unsaturated, substituted alkyl or cycloalkyl groups which may be saturated or unsaturated. In formulae 5, 6 and 9, X is O, NR (wherein R is acyl, alkyl or sulphonate groups), S, SO or SO 2 . In formulae 5, 6 and 9, any one or more of R<SP>1</SP>, <SP>1</SP>R<SP>1</SP>: R<SP>2</SP>, <SP>1</SP>R<SP>2</SP>; R<SP>3</SP>, <SP>1</SP>R<SP>3</SP>, R<SP>9</SP>, <SP>1</SP>R<SP>9</SP>; R<SP>10</SP>, <SP>1</SP>R<SP>10</SP> and R<SP>14</SP>, <SP>1</SP>R<SP>14</SP> may together represent oxo. |