| abstract |
A method of making a library of compounds comprises the following steps: (a) individually identifying a plurality of discrete reaction zones defined on laminar solid support material; (b) charging each of said reaction zones with a starting material; (c) sub-dividing the reaction zones into at least two initial batches; (d) applying at least two different reagents, one to each of the reaction zones in each initial batch, and recording the identity of those reaction zones to which each of said different reagents is applied; (e) subjecting all reaction zones to reaction conditions which promote reaction to completion; (f) further sub-dividing the reaction zones into at least two alternative batches; (g) applying at least two different reagents, one to each of the reaction zones in each alternative batch, and recording the identity of those reaction zones to which each of said different reagents is applied; (h) subjecting all reaction zones to reaction conditions which promote reaction to completion, and (i) repeating steps (f) to (h) inclusive as many times as desired. The solid support may comprise paper prepared from cellulose comprising an amino group, obtained by reaction of the cellulose either with an amino precursor, followed by generation of free amine which is blocked by a protecting group, or with a compound having a protected amine group, followed by deprotection. The lamina may comprise a functionalised resin (aminomethylpolystyrene) sandwiched (with a polyethylene) between porous inert sheets (non-woven fibrous polypropylene). |