| abstract |
Isolated DNA encoding each of human calcium chanel alpha 1-, alpha 2-, beta - and gamma -subunits, including subunits that arise as splice variants of primary transcripts, is provided. In particular DNA clones encoding each of the alpha 1A-1, alpha 1A-2, alpha 1E-1, alpha 1C-2, alpha 1E-3, beta 3-1, beta 2C, beta 2D, beta 2E and beta 4 subunits of human calcium channels are provided. Cells and vectors containing the DNA, subunit specific antibodies and nucleic acid probes and methods for identifying compounds that modulate the activity of human calcium channels are also provided. |