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filingDate 1993-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef3fca81aecb66bf8abcb6f30dff0cf8
publicationDate 1995-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-2281294-A
titleOfInvention Process for producing half esters of the macrolide FK506
abstract Half esters of the compound FK506 with dicarboxylic acids are produced bv reacting a mixture comprising FK506 and a dicarboxylic acid or anhydride thereof, such as succinic anhydride, in the presence of a dialkylaminopyridine such as 4-dimethylaminopyridine, in the absence of other bases. The FK506 half esters thus produced are useful as intermediates in the preparation of various conjugates for utilization in diagnostic assays for the compound FK506. The succinate ester has the formula:- <IMAGE>
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