| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-645 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-35 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-06 |
| filingDate |
1994-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a2db281f954004d280bd77d36b3764f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f056d97b2f2d2c0594a0f1f4b202268
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_005275eb5cb5f4a9b2b0d99a496da6f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c36897874604e7edf09e1a01f1c21981
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f381d8052740baa8ae20f8afd724dcd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a3f2f67efa7ca06ae4ccc485755aa58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8d5f8e181f5153449ffec575b3f764f |
| publicationDate |
1994-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GB-2278276-A |
| titleOfInvention |
Gamma-pyrone-3-acetic acid as an inhibitor for interleukin-1 beta converting enzyme |
| abstract |
Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1 beta converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 beta functions as an autocrine growth factor or as a mediator of cachexia. <IMAGE> Also claimed is a biologically pure culture of MF5809, XYLARIA Sp., ATCC accession No 74223 capable of producing gamma-pyrone-3-acetic acid. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3603634-A1 |
| priorityDate |
1993-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |