http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2266090-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 |
| filingDate | 1993-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39206be44963c13e7196d57e8c5d6b2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86750ece9380e9166a4887c7201e7190 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7b68186a3946122e522b9e31c19ab18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17db1dc4fb6586f71c887af38eda3470 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08b5b668acfde31eb7be4798045f4d6c |
| publicationDate | 1993-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2266090-A |
| titleOfInvention | A novel synthesis of substituted benzlactams |
| abstract | A multi-step process for the preparation of substituted benzlactams is disclosed where the yields are improved, hazardous reagents are avoided, the stereochemical purity of the resolution step is improved and the need for special reagents for a side chain attachment step is avoided. The process starts with an unsubstituted benzlactam (II) which is iodinated using hexamethyldisilazane and iodine to give (III); the 3-iodo group is then displaced by ammonia. Resolution with D-tartaric acid yields the optically pure 3-amino benzlactam (V). The 3-amino is coupled with an N-chloro-sulfonyl p-lactam and a substituted biphenylmethyl group is attached to the ring nitrogen. The product (I) is active as a growth hormone secretagogue. <IMAGE> |
| priorityDate | 1992-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 174.