| abstract |
Salts and amides AB, wherein A is a cyclooxygenase inhibitor having an accessible acidic function and B is an L- arginine analogue, are inhibitors of the L-arginine/nitric oxide pathway and the cyclooxygenase pathway. They are thus potentially beneficial in the treatment of cardio and cerebrovascular disorders, inflammation and immune disorders. A is preferably acetylsalicylic acid, salicylic acid, mefanamic acid, ibuprofen. indomethacin or sulindac. B is preferably N- monomethyl-L-arginine, N- omega -nitro-Larginine or N- omega -nitro-L-arginine methyl ester. Their preparation and pharmaceutical compositions containing them are described. |