| abstract |
1, 4, 7-trithiacyclonane (9S3) and related compounds may be substituted with a linker group which can bind to a substrate such as a protein, especially an antibody and which itself retains co-ordinating functionality to chelate a radionuclide for diagnosis or therapy. The compounds are of the formula:- <IMAGE> wherein one T is S or Se or Te, another T is S or Se or Te and the third T is S, Se, Te, >PX or >AsX, X being a univalent atom or group, and where A<1> is -C2H4- or <IMAGE> or -C3H6-, A<2> is -C2H4- or <IMAGE> and A<3> is -C2H3R- <IMAGE> or except when A<1> is -C3H6-, -C3H5R-, where R is alkyl or substituted alkyl or, if the third T contains P or As, R may also be H. |