| abstract |
The compositions comprise cores including a pharmacologically active ingredient and having a diameter not greater than 5 mm, the cores being coated with a mixture comprising a) as a film forming agent at least one poly (ethyl acrylate, methyl methacrylate, trimethylammonioethyl methacrylate chloride) and b) at least one anionic surfactant wherein the ratio of a) to b) is from 100:1 to 10:1 by weight. The surfactant may be an alkylaryl sulphonate, sodium lauryl sulphate, a sulphosuccinate, a sulphosuccinamate, a sarcosinate or a taurate and the active ingredient may be (inter alia) idazoxan mebeverine, paracetamol, aspirin or betahistine. The film forming agent may be Eudragit RS or Eudragit RL (Trade Marks). |