| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c26895e1df2ffdb5a7a07dc40911694c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6897
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-61 |
| filingDate |
1991-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44a73db3c209309d9ed4760a7512d6e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b8dc6125debc38a338be1e22ba68432 |
| publicationDate |
1992-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GB-2247023-A |
| titleOfInvention |
Nucleic acid sequences for the production of transgenic animals prone to thrombi, dilated cardiomyopathy or the like |
| abstract |
A nucleic acid consists of DNA comprising a gene sequence coding for an Epstein-Barr virus nuclear antigen leader protein or homologue or derivative preferably fused to an upstream segment containing a mouse metallothionein-I gene sequence providing promoter and control sequences and fused to a downstream segment containing a human growth hormone gene sequence (hGH). Transgenic animals such as mice produced by incorporating this DNA into the genome thereof have a substantially increased probability of spontaneously developing blood clotting or thrombi in their circulatory system, especially in the left atrium of the heart, and/or symptoms of dilated cardiomyopathy or similar heart dysfunction. Such animals can be useful for screening and identifying or testing drugs or other substances for antithrombotic or thrombolytic activity or for cardiotherapeutic activity for use in human medicine. |
| priorityDate |
1990-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |