| abstract |
There is provided a method of selectively modifying a tissue of an animal, comprising introducing foreign DNA directly to the selected tissue or to material that will develop into the selected tissue, to produce localised somatic transgenesis of the tissue. The method may be applied to a developing foetus, with DNA introduced to a precursor of the selected tissue, or to a new born animal, or a juvenile animal or possibly even a mature adult animal. Suitable target tissues include the mammary gland, skin, liver and salivary gland. By introducing DNA the method can be used to endow the selected tissue with particular properties, with the tissue expressing the introduced DNA and typically producing and secreting a desired polypeptide product. |