http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2216524-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac40ffdd0f9b7563bab9d5dccaa8a6b3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 1989-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a926e4e7fed22b006e21c5a7aab9250c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_764fe5ef426d668f39a9b8fea39b7b5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5912b12bc7785bd35ead3311bb3feb03 |
| publicationDate | 1989-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2216524-A |
| titleOfInvention | Preparation of 2,6-dioxopiperidine derivatives |
| abstract | 3-Alkyl- or fluoroalkyl-3-(4-pyridyl)piperidine-2,6-diones, useful in the treatment of breast cancer, of formula <IMAGE> wherein R represents an alkyl group having 2 to 10 carbon atoms or a flouroalkyl group having 2 to 5 carbon atoms and A is hydrogen or an alkyl group having 1 to 4 carbon atoms, are prepared by reacting a 4-pyridylacetate with an alkyl or fluoroalkyl iodide, chloride or bromide, in the presence of a sterically bulky base and reacting the product with acrylamide in the presence of a sodium or potassium branched chain alkoxide. Preferably potassium t-butoxide is used in both stages and they are carried out sequentially at room temperature in an alcpholic or polar, aprotic solvent in a single reaction vessel. |
| priorityDate | 1988-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.