| abstract |
A pharmaceutical composition designed for sustained and controlled release of drug over an extended period of time comprises a polylactide, a polyglycolide, a copolymer of lactic and glycolic acid or a mixture of these polymers and a water-insoluble peptide which, when placed in an aqueous physiological-type environment releases the peptide in continuous manner for a period of at least one week, and with an initial release for the first twenty-four hours of not more than 30% of the total amount released. |