| abstract |
Biologically active materials, including proteins (for example, enzymes), cells, antigens, antibodies, and hormones, are immobilised on a polymer support which comprises the reaction product of a polyepoxide (such as the diepoxide obtained from interaction of epichlorhydrin and 2,2-di[p-hydroxyphenyl]-propane) with a polyester which is obtained by the condensation of A. a hydroxy-terminated diester of a diol (eg ethylene glycol) and a dicarboxylic acid (eg succinic acid) with B. a polycarboxylic acid having at least 3 carboxylic acid groups (eg trimellitic acid) or an anhydride thereof. The reaction product may be activated (optionally after conversion of any carboxyl groups to acid chloride groups) by treatment first with 1,6-diaminohexane and then with glutaraldehyde. |