| abstract |
Compounds of formula <IMAGE> or salts thereof [wherein: ??? and ??? together represent a bond and additionally when B is an electron withdrawing group ??? can also represent OH and ??? can represent hydrogen; Ar is optionally substituted aryl or hetaryl; R is hydrogen or alkyl, cycloalkyl, aralkyl or hetarylalkyl, each optionally substituted; R<1> and R<R> are the same or different and are selected from hydrogen and saturated or unsaturated, cyclic or acyclic aliphatic hydrocarbon residues optionally substituted by one or more groups selected from halogen, OH, carboxy, CN, alkoxy, cycloalkoxy, alkylthio, cycloalkylthio, aryloxy, hetaryloxy, alkoxycarbonyl, cycloalkoxycarbonyl, amino, substituted amino, and optionally substituted aryl or hetaryl; A represents a group of formula -XR<3> wherein X is a group of formula -(CHR<6>)p-Y-(CHR<7>)q- in which formula: Y is -O-, -S-, NR<8> or a direct bond, p and q are each 0, 1 or 2 R<6>, R<7> and R<8> are independently hydrogen, lower alkyl or lower cyclo-alkyl and R<3> is an optionally substituted ring nitrogen containing heteroaryl radical optionally containing other ring heteroatoms selected from oxygen, nitrogen or sulphur; B represents haloalkyl, halocycloalkyl, optionally substituted phenyl, -CN, -CHO, -CH(Oloweralkyl)2, -CH(Ocycloalkyl)2 or -CH2OH] have hypotensive activity and are also useful as vasodilators and calcium movement antagonists. |