| abstract |
2-Substituted thiazolidines compounds have the formula <IMAGE> wherein: X is a CH2, O, S; R is hydroxy, or an ester thereof of formula Rc-CO2-C1-C6-alkoxy, CH2=CH-CH2O-; HC IDENTICAL C-CH2-O-; methyl R, is hydrogen and <IMAGE> R2 is hydrogen or a free or esterified carboxy group; R3 is hydrogen, a C1-C2alkylsulphonyl group, a phenyl, p-Cl phenyl, p-methylsulphonyl group or an acyl group of formula RdCO; p is zero or 1 with the proviso that when X is sulphur p is zero; both Ra and Rb are hydrogen or methyl; Rc and Rd, which are the same or different are: hydrogen or are chosen from various defined organic groups, or are salts with non toxic bases or acids thereof, enantiomers, diastereoisomers or mixtures thereof. The compounds are useful as antitussive or mucus regulating agents. |