http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2103622-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-32122 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-09 |
| filingDate | 1982-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ac7b2a10c77e092df92b6f6e3d6a42e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb8e10d45903adc82d9471d81b30ac7e |
| publicationDate | 1983-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2103622-A |
| titleOfInvention | Production of foot and mouth disease vaccine from microbially expressed antigens |
| abstract | Polypeptides which act as antigens of foot and mouth disease virus (FMDV) are produced by microorganisms which have been transformed with plasmids produced using recombinant DNA technology. A suitable plasmid has a gene sequence (produced by chemical synthesis or by reverse transcription) which encodes a polypeptide comprising one or more immunogenic determinants of one or more FMDV proteins, and optionally a fusion protein preferably linked via a cleavage site, the gene sequence being under the control of a promoter. For example, an E. coli K12 strain was transformed with plasmid pFM1. This is based on plasmid pBR322, with the DNA sequence of codons 8 to 210 of the VP3 gene of FMDV type A12119ab connected to the LE' protein (from pBR322) so as to be in the same reading frame. This assembly is under the control of the E. coli trp operon. The transformant E. coli was cultured and caused to expressthe LE'-VP3 fusion protein. This was isolated and shown by competitative radio immunoassay to have similar antigenic properties to purified natural VP3 protein. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8403506-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4701416-A |
| priorityDate | 1981-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1103.