| abstract |
A process is provided for preparing ergoline derivatives I <IMAGE> substituted phenyl, unsubstituted phenyl, (CH2)nN(CH3)2 wherein n is an integer, R5 = any of values of R6 or H, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, thiazolyl or thiadiazolyl. The process comprises condensing an ergoline amide (I; 8-substituent replaced by CONHR5) with R6-N=C=O in a solvent at 70 DEG C to 120 DEG C for 24 to 72 hours. |