| abstract |
The present invention relates to a pharmaceutical composition for implantation in a natural, pathological or artificial cavity in body tissue. The composition comprises CaSO4 (e.g. as gypsum or plaster of Paris), and at least one antibiotic substance selected for its ability to be slowly released from the CaSO4 and to maintain antibiotically effective concentrations in fluid in the cavity for a period of up to several weeks. The preparation of the composition comprises mixing plaster of Paris (calcium sulphate, hemihydrate) with the desired antibiotic substance or substances and water, optionally adding auxiliary agent(s) and allow the slurry obtained to set in moulds, or in situ. The antibiotic is fusidic acid and/or gentomycin. |