| abstract |
1-sulfo-2-oxoazetidine derivatives of the general formula (I> <IMAGE> wherein R1 is amino group which may optionally be acylated or protected, X is hydrogen or methoxy, and R4 is azido, a halogen, amino group which may optionally be acylated or a group of the formula -OR5, or-S-S-R5 in which R5 is an organic residue and n is 0, 1 or 2, or a pharmaceutically acceptable salt thereof, or an ester thereof as well as methods of production in accordance with the following schemes: <IMAGE> wherein R2 is an acylated or protected amino group, R3 is an acylated amino group, and R1 and R4 are as above defined. The compounds (I) have antimicrobial and beta -lactamase inhibitory activity. |