| abstract |
Novel 6 alpha -methylhydrocortisone derivatives of the general formula In n<IMAGE>n (in which R1 represents C2-C6-1- oxoalkyl or benzoyl and R2 represents H or C2-C6-1-oxoalkyl) are prepared by one or more steps selected from:n (i) microbial 11-hydroxylation, (ii) hydrolysis of 17,21-orthoesters, (iii) rearrangement of 21-esters to 12- esters, (iv) 17-esterification (with 11-OH being protected), (v) 21- esterification. n<??>Activity: antiinflammatory. |