http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2086378-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69c91bbf0395db010b4806f50d808c4e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-04 |
| filingDate | 1981-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1982-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2086378-A |
| titleOfInvention | Process for the Preparation of Cytostatic Compounds |
| abstract | A process for the preparation of new cytostatic compounds of general formula (I> <IMAGE> in which either R<4> represents a beta -hydroxyl group and R<3> represents an alpha -ethyl group or R<4> represents a hydrogen atom and R<3> represents a beta -ethyl group; R'' represents a methyl group, a straight chain alkyl group having from 3 to 10 carbon atoms, a branched chain alkyl group having from 3 to 10 carbon atoms and in which the carbon atom attached to the <IMAGE> group has a primary or secondary configuration, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety; R<1> represents a methoxy group; and R<2> represents an acetyl group; which comprises reacting a compound of formula (II), <IMAGE> (in which R<1>, R<2>, R<3> and R<4> are as defined above), or an acid addition salt thereof with a large excess of an alcohol of formula R''-OH (III> (wherein R'' is as defined above) in the presence of chromium trioxide at a temperature of from -60 DEG C to -30 DEG C. |
| priorityDate | 1980-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.