| abstract |
A process for the preparation of 4,1',6'-trichloro-4,1',6'- trideoxygalactosucrose (TGS) comprising the steps of: (a) reacting sucrose with an acylating reagent under conditions to provide a mixture of acylated sucrose derivatives containing a major proportion of 6-monoacylated material; (b) optionally separating 6- monoacylated sucrose derivative from other acylated derivatives before step (c); (c) reacting the monoacylated sucrose derivative with a chlorinating reagent capable of chlorinating at position 1', 4 and 6' of a sucrose 6-acylate; and (d) deacylating and separating (in either order) the 4,1',6'-trichloro-4,1',6'- trideoxygalactosucrose material formed. o |