http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2065098-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d709e3167fa2f99a1803c9cfeb0aca63 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-587 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-36 |
| filingDate | 1979-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1981-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2065098-A |
| titleOfInvention | N-substituted Thiazolyl Derivatives of 7-amino- cephalosporanic Acid |
| abstract | Compounds of general formula (I> <IMAGE> wherein A is <IMAGE> wherein R2 represents a hydrogen atom or a free or protected hydroxy group; R is 1) -OR3 in which R3 is hydrogen or a branched or straight chain saturated or unsaturated C1-C6 aliphatic hydrocarbon group which is unsubstituted or substituted by one or more substituents selected from a) cyano, b) -COOR' in which R' is hydrogen, C1-C6-alkyl or a carboxy-protecting group; <IMAGE> in which each of the groups R4 and R5, which may be the same or different, represents a hydrogen atom, a C1-C6 alkyl or a C2-C6 aliphatic acyl group, or, when R4 is hydrogen, R5 may be also an amino-protecting group; or <IMAGE> wherein R4 and R5 are as defined above; R1 is hydrogen or an amino- protecting group; n is zero, 1 or 2; Y is a') hydrogen; b') halogen; c') hydroxy; d') C1-C6-alkoxy; e') C1-C6 alkyl; f') -CH2OCOCH3; g') a group <IMAGE> where R'' may be hydrogen, C1-C6 alkyl, carboxy, cyano or carbamoyl; h') a group -CH2-S-Het, wherein Het represents 1) a pentatomic or hexatomic heteromonocyclic ring containing at least one double bond and at least one heteroatom selected from N, S and O, which ring may be unsubstituted or substituted by one or more substituents selected from: a'') hydroxy, C1-C6 alkoxy, halogen, C2-C6 aliphatic acyl; b'') C1-C6 alkyl unsubstituted or substituted by one or more substituents selected from hydroxy and halogen; c'') C2-C6 alkenyl unsubstituted or substituted by one or more substituents selected from hydroxy and halogen; d'') -S-R6 wherein R6 is hydrogen or C1-C6 alkyl -S- CH2COOR' wherein R' is as defined above; e'') -(CH2)m-COOR', -CH=CH-COOR', -(CH2)m- CONH2 or -(CH2)m-CN wherein m is zero, 1, 2 or 3 and R' is as defined above; f'') (CH2)mSO3H wherein m is as defined above; or g''> <IMAGE> wherein m, R4 and R5 are as defined above; or 2) a heterobicyclic ring containing at least two double bonds wherein each of the condensed heteromonocyclic rings thereof is the same or different pentatomic or hexatomic heteromonocyclic ring containing at least a heteroatom selected from N, S and O, the heterobicyclic ring being unsubstituted or substituted by one or more substituents selected from a''), b''), c''), d''), e''), f'') and g'') defined above; X is a free or esterified carboxy group; provided that when A is a -CH2- group, R is not -OH; and the pharmaceutically and veterinarily acceptable salts of compounds of general formula (I) are useful antibacterial agents for treatment of humans and animals. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011054525-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IT-PI20090140-A1 |
| priorityDate | 1979-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 136.