| abstract |
3-Aryl-3-aryloxypropylamines of the general formula (I> <IMAGE> and their pharmaceutically acceptable acid addition salts, wherein R<1> and R<2> are hydrogen or lower alkyl, R<3> is hydrogen, lower alkyl or benzyl, R<4> is hydrogen or lower alkyl, Ar is a phenyl group substituted by at least one trifluoromethyl, lower alkyl, lower alkoxy, nitro or amino group and Ar<1> is a phenyl radical optionally substituted by one or more trifluoromethyl, lower alkyl, lower alkenyl, halogen, nitro, amino or acylamino groups exhibit activity on the central nervous system, e.g. as antidepressants. |