| abstract |
New bicyclic thiadiaza compounds of the general formula (I> <IMAGE> the 1,3-diazacyclopent-2-ene ring of which may have a further double bond, Alk represents lower alkylene that separates the sulphur atom from the nitrogen atom by 2 to 4 carbon atoms, Ar1 and Ar2 represent, independently of one another, an optionally substituted phenyl, pyridyl or thienyl radical and n is 0, 1 or 2, provided that at least one of the radicals Ar1 and Ar2 is not phenyl when Alk represents ethylene and the 1,3-diazacyclopent-2-ene ring represents an imidazole ring, and the salts thereof, anti-inflammatory and anti- rheumatic effects. They also an analgesic effect and have an inhibitory effect on prostaglandin synthetase in vitro. Compounds of the general formulae <IMAGE> or their tautomers, and the salts thereof are also claimed. |