| abstract |
The invention relates to a new process for the preparation of compounds of value as pharmaceuticals or intermediates. The process comprises a process for preparing compounds of formula I <IMAGE> and acid addition salts thereof, wherein R is alkyl, cycloalkyl, aralkyl or aryl (including heteroaryl), R<1> is an organic radical, X is oxygen or sulphur and A is an alkylene, mono- or dioxo- or hydroxyalkylene radical of 1-5 carbon atoms, which process comprises reacting a compound of formula II <IMAGE> wherein R<1> and A are as defined above with an acylurea of formula H2NCXNHCOR wherein R is as defined above and X is oxygen or sulphur and if desired converting the product to an acid addition salt. |