| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_058e0be30e00d53858c67167df60aed5 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7028
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 |
| filingDate |
1978-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
1979-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GB-2007645-A |
| titleOfInvention |
Novel N-benzyl anthracyclines and pharmaceutical compositions containing them |
| abstract |
The invention provides novel N- benzyl derivatives of adriamycin and daunomycin having anti-cancer activity and being compounds of the formula <IMAGE> where R = -COCH3, -CHOHCH3, -COCH2OH or -CHOHCH2OH and X = NHCH2Ph or -N(CH2Ph)2, and their pharmaceutically acceptable acid addition salts. Also included are pharmaceutical compositions containing these derivatives and salts as the active ingredient. The compounds are made by reductive N-benzylation of the free amines. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5124317-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5124318-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6107285-A |
| priorityDate |
1977-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |