| abstract |
N-Phenyl-N-(4-piperidinyl)amides have the following formula <IMAGE> in which the substituents are defined in Claim 1; the compounds can also be present as acid addition salts. The compounds of the formula I, in which Z is oxygen, are prepared by reacting a corresponding 4,5-dihydro-1H-tetrazol-5-one with a corresponding N-phenyl-N-(4-piperidinyl)amide. Compounds of the formula I, in which Z = O, are likewise obtained by N-acylating a corresponding 4-piperidinamine. Compounds in which Z = S are prepared from compounds of the formula I, in which Z = O, by reaction with a sulphurating agent. Pharmaceutical compositions having an analgesic effect contain, as the active compound component, at least one novel compound of the formula I or a pharmaceutically acceptable acid addition salt thereof. |