| abstract |
Peptides which contain at least four amino acids and are characterised by the presence of an amidino-substituted alpha -amino acid, such as arginine, at the carboxyl terminus, are effective for regulating the contraction of the smooth musculature, the release of histamine and the permeability of the vessels. They contain an amidino-substituted alpha -amino acid as the first amino acid at the carboxyl terminus, which acid is bonded by a peptide bond to the carboxyl group of glycine or alanine. This second amino acid is bonded via its amino group with the carboxyl group of a third, hydrophobic amino acid. This latter acid is in turn bonded via its amino group with the carboxyl group of a fourth amino acid. |