http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1534988-A

Outgoing Links

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-10
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-935
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filingDate 1977-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1978-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1534988-A
titleOfInvention Thromboxane intermediates
abstract 1534988 Silylated tetrahydropyran derivatives UPJOHN CO 14 April 1977 [20 Aug 1976 14 April 1976] 39548/77 Divided out of 1534984 Heading C3S [Also in Division C2] The invention comprises tetrahydropyran derivatives of the formula wherein W is CH 2 CH 2 OSi(G) 3 , Z is Si(G) 3 , wherein the G's are the same or different and are C 1-4 alkyl, C 3-10 cycloalkyl, C 7-12 aralkyl or phenyl optionally substituted once or twice by C 1-4 alkyl radicals or F or Cl atoms; Y 1 is trans CH 2 CH or CH 2 CH 2 ; R 3 and R 4 each are H, F or CH 3 with the proviso that -CR 3 R 4 - is not -CFCH 3 -; R 7 is (CH 2 ) m CH 3 or Z-Ph-(T) s , wherein m is 1 to 5, Z is O or (CH 2 ) n , wherein n is 0 to 3; s is 0 to 3, and T is C 1-3 alkyl, C 1-3 alkoxy, Cl, F or CF 3 , with the provisos that not more than two T's may be other than alkyl, that the T's may be the same or different and that Z is not O when R 3 and/or R 4 is F; R 33 is C 1-5 alkyl and M 6 is or a mixture of and where R 10 is 2-tetrahydropyranyl, 2-tetrahydrofuranyl or where R 11 is C 1-18 alkyl, C 3-10 cycloalkyl, C 7-12 aralkyl or phenyl optionally substituted 1 to 3 times by C 1-3 alkyl radicals; either R 12 and R 13 each are C 1-4 alkyl or phenyl optionally substituted 1 to 3 times by C 1-3 alkyl radicals or R 12 and R 13 are taken together and are (CH 2 ) a or (CH 2 ) b O(CH 2 ) c , wherein a is 3, 4 or 5 and b and c are 1, 2 or 3, with the proviso that b+c is 2, 3 or 4; and R 14 is H or phenyl; and their preparation by silylating the corresponding free hydroxy compounds.
priorityDate 1976-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

Incoming Links

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Total number of triples: 29.