| abstract |
1530861 Cephalosporin and penicillin derivatives TAKEDA YAKUHIN KOGYO KK 5 Jan 1977 [5 Jan 1976] 00214/77 Heading C2C Compounds of the general formula where R<SP>1</SP> is H or methoxy, X is of formula or and Y is acyloxy, a heterocyclic quaternary ammonium group or -SR<SP>2</SP> where R<SP>2</SP> is heterocyclic, and pharmaceutically acceptable salts thereof, are prepared by reacting the corresponding 6-amino penicillin or 7-amino cephalosporin with or a reactive derivative thereof; additionally, the compounds in which X is may be prepared by reacting where -CH 2 Z represents a reactive derivative of a hydroxymethyl group (e.g. Z is acyloxy, halogen, tosyl or azido) with a heterocyclic tertiary amine or R<SP>2</SP>SH. The compounds have pharmaceutical properties. |