http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1530572-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df4e72183c5ee38a234212562dca6570 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D339-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D339-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 |
| filingDate | 1977-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1530572-A |
| titleOfInvention | Cephalosporin derivatives their preparation and compositions containing them |
| abstract | 1530572 Cephalosporin derivatives RHONE POULENC INDUSTRIES 17 Jan 1977 [19 Jan 1976] 01778/77 Heading C2C Novel cephalosporin derivatives of the general Formula I wherein R 1 is acetoxy, (5-methyl-1,3,4-thiadiazol-2-yl)-thio, (1-methyl-tetrazol-5-yl)-thio or [1-(2-hydroxyethyl)-tetrazol-5-yl]-thio and R 2 is carboxyl; or R 1 is pyridinio and R 2 is the carboxylato ion; and, when R 2 is carboxyl, their metal salts and addition salts with nitrogencontaining bases are prepared (a) by reacting (1,3-dithiin-5-yl)-acetic acid or a reactive derivative thereof with a cephalosporin of the general Formula III or, when R 2 is carboxyl, a derivative thereof in which the carboxyl group is protected, followed if necessary by removal of the protecting group; or (b) when R 1 is other than acetoxy, by reacting the corresponding compound in which R 1 is acetoxy with 5-methyl-2-thioxo-1,3,4- #4-thiadiazoline, 1-methyl-5-thioxo-tetrazoline, 1-(2-hydroxyethyl)-5-thioxo-A2-tetrazoline or pyridine; followed optionally by salification of the product. The preparation of (1,3-dithiin-5-yl)-acetic acid and the acid chloride thereof is described. Pharmaceutical compositions having antibacterial activity comprise, as active ingredient, a cephalosporin derivative (I) or pharmaceutically acceptable salt (as defined above) thereof, in association with a compatible pharmaceutically acceptable diluent or adjuvant. |
| priorityDate | 1976-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.