http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1528259-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cec1f0aff18c0f523c702e3f4f221b45 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate | 1976-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1528259-A |
| titleOfInvention | Process for the preparation of a gamma-globulin solution suitable for intravenous administration |
| abstract | 1528259 Intravenous γ-globulin BIOTESTSERUM INSTITUT GmbH 3 Sept 1976 [6 Sept 1975 3 April 1976] 36594/76 Addition to 1244245 Heading A5B [Also in Division C3] A process for the preparation of a gammaglobulin solution suitable for intravenous administration comprises treating a solution of natural or standard gamma-globulin with a treatment agent chosen from acetimide acid ester or an acid addition salt thereof, diketene, formimide acid ester or an acid addition salt thereof, and alkane sultone; and recovering the product. Examples describe (1) the preparation of a gamma-globulin solution suitable for intravenous administration, wherein 0.055g of acetimide acid ethyl ester hydrochloride or 0.022 g of diketene/g of protein is added to a standard gamma-globulin solution at a pH- value of 9.0 and at a temperature of 5‹C, or 0.077g of propane sultone/g of protein is added to a standard gamma-globulin solution at a pH-value of 9.0 and at a temperature of 37‹C, followed by standing for 2 hours, pH adjustment to 7 dialysis and filtrating under sterile conditions, and (2) the preparation of a gamma-globulin solution suitable for intravenous administration, wherein 0.05 g of formimide acid ethyl ester hydrochloride/g of protein is added to a standard gammaglobulin solution at a pH-value of 9.0 and at a temperature of 5‹C, followed by standing for 2 hours, pH adjustment to 7.5, dialsyis and filtration under sterile conditions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2658334-A1 |
| priorityDate | 1975-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.