http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1514476-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_232361c9031a709144573276863c462b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J3-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J3-00 |
| filingDate | 1974-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1514476-A |
| titleOfInvention | Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates |
| abstract | Steroids with antiinflammatory activity and the formula I in which R' is methyl, ethyl, n-propyl or isopropyl; R'' is methyl, chloromethyl, fluoromethyl, bromomethyl, iodomethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl or 2-iodoethyl; X is hydrogen or fluorine; and @ is a single or double bond are prepared by esterifying or transesterifying, respectively, with an agent supplying the radical R'' or the radical R', respectively, a corresponding 17 alpha -acyloxy-17ss-carboxylic acid or a functional derivative thereof or a 17 alpha -hydroxy-17ss-carboxylate. Resulting DELTA <1>-steroids of the formula I can subsequently be reduced to the corresponding saturated compounds or resulting 1,2-saturated compounds can be dehydrogenated to the corresponding DELTA <1> compounds. In addition, halogen substituents present in the group R'' can be replaced by other halogens; thus, for example, compounds of the formula I in which R'' is an alkyl group substituted by chlorine, bromine or iodine can be converted by this exchange reaction to the corresponding fluoroalkyl compounds. The compounds of the formula I are distinguished by very good antiinflammatory activity and can be converted into pharmaceuticals for topical or internal administration. <IMAGE> |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03062259-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2004255855-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03082896-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009514781-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009513533-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03072592-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03062259-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03082896-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2004255854-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101075324-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101029207-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7524970-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7638508-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7579335-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005005452-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005005451-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7291609-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7288536-B2 |
| priorityDate | 1974-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.