http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1514278-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-277 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 |
| filingDate | 1975-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1514278-A |
| titleOfInvention | Pyrrolidones and process for preparing them |
| abstract | 1514278 10-Azaprostaglandins HOECHST AG 6 Nov 1975 [6 Nov 1974 24 June 1975] 46044/75 Heading C2C The invention comprises 10-azaprostaglandins of the Formulµ I and XIV wherein R<SP>1</SP> is C 1-6 alkyl or a C 3-7 cycloalkyl radical optionally substituted by one or more C 1-4 alkyl or C 1-4 alkoxy radicals; R<SP>2</SP> is H or C 1-4 alkyl; R<SP>2</SP>' is C 1-4 alkyl; R<SP>3</SP> is C 1-10 alkyl which may be substituted by: (i) C 1-5 alkoxy, allyloxy or C 1-5 alkylthio; (ii) a phenoxy radical optionally substituted by one or more halogen atoms or C 1-3 alkyl, C 1-3 haloalkyl, phenoxy or halophenoxy radicals; (iii) a phenyl, furyl, furyloxy or benzyloxy radical which may be substituted by one or more C 1-3 alkyl radicals; (iv) a trifluoromethyl or N-methylpropionylamino radical; or (v) a C 3-7 cycloalkyl; m is 1 or 2 and n is 2 or 3, and wherein the side chains in the 3- and 4-positions of the pyrrolidone ring are trans to each other, and the double bond in the side chain in the 3-position is in the cis configuration; and salts thereof when R<SP>2</SP> is H, and their preparation by standard methods. Various 2-pyrrolidones are prepared as intermediates in the preparation of the above 10- azaprostaglandins. Pharmaceutical compositions, suitable for oral or parenteral administration, contain the 10- azaprostaglandins of Formula I above or salts thereof in admixture or conjunction with pharmaceutically suitable carriers. The compounds possess bronchodilating and blood pressure lowering actions and luteolytical properties. They also inhibit the secretion of gastric juice. |
| priorityDate | 1974-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.