http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1513110-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b3a84ce1bda750fe5a70cfb1d62ebc2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-673 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-71 |
| filingDate | 1976-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1513110-A |
| titleOfInvention | Therapeutically active phenylethanolamine derivatives |
| abstract | 1513110 Phenylalkanoylamines LES LABORATOIRES BRUNEAU & CIE 19 Oct 1976 [22 Oct 1975] 43348/76 Heading C2C Compounds of the general Formula (I) (Z = C 2-4 hydroxyalkyl, C 3-4 dihydroxyalkyl; R = H, C 1-6 alkyl; R 1 = H, C 1-6 alkyl, C 3-6 cycloalkyl, R 2 R 3 R 4 PhC x H 2x ; x = 2-5; R 2-4 = H, OH, OMe, OEt or two in adjacent positions = O(CH 2 ) 1 , 2 O) and their salts and N- benzyl and dibenzyl (R 1 = H) derivatives are prepared by brominating a compound of the Formula (II) (Z<SP>1</SP> = acylated Z; Ac = acyl, benzyl), condensing the α-bromoketone obtained with the appropriate primary amine or its benzyl derivative or dibenzylamine, in any order removing the protecting groups and reducing the CO group to CHOH, if desired reductively alkylating a resulting primary amine, effecting isomer separation and/or converting the product to a salt. The preparation of the starting materials of Formula (II), the corresponding compounds in which the phenolic hydroxy group and/or the hydroxy group(s) in the side chain are not protected o - (2 - acetoxyethoxy)phenyl acetate and o - (2 - propionoxyethoxy)phenyl propionate is described. The compounds of Formula (I) and their salts are bronchospasmolytics, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0052963-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4382958-A |
| priorityDate | 1975-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.