http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1505885-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 |
| filingDate | 1975-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1505885-A |
| titleOfInvention | Substituted cephalosporins |
| abstract | 1505885 Acylureidocephalosporins ELI LILLY & CO 1 April 1975 [1 April 1974] 13382/75 Heading C2C Novel acylureidocephalosporins of the formula wherein R 1 is C 1-4 alkyl, phenyl optionally substituted by halogen atoms or nitro groups or 2-phenylvinyl in which the benzene ring is optionally substituted by halogen atoms or nitro groups; R 1 is phenyl, hydroxyphenyl, halophenyl, hydroxy-halophenyl, thienyl or furyl; R 2 is 1-(C 1-4 alkyl)-1H-tetrazol-5-yl or 5 - (C 1-4 alkyl) - 1,3,4 - thiadiazol - 2 - yl; and R 3 is H, indanyl, phthalidyl or (C 2-5 alkanoyloxy)methyl or benzoyloxymethyl; and pharmaceutically acceptable, non-toxic salts thereof are prepared by reacting cephalosporins of the formula with carbamoyl chlorides of the formula in the presence of acid binding agents, and, if desired, esterifying or salifying the resulting free acids. N - (o - Chlorobenzoyl) - N - methylcarbamoyl chloride is prepared reacting phosgene, in the presence of butyl lithium, with N-methyl-ochlorobenzamide resulting from the reacting between methylamine and o-chlorobenzoyl chloride. Pharmaceutical compositions, suitable for oral or parenteral administration, contain the above cephalosporins or salts thereof together with pharmaceutically acceptable diluents therefor. The compounds possess activity against grampositive and gram-negative micro-organisms. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4341776-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4301161-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4298605-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4328224-A |
| priorityDate | 1974-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.