http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1503873-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30432c021c19453629a3b69ce104640e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-23 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-00 |
| filingDate | 1976-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1503873-A |
| titleOfInvention | Butirosin a derivatives and methods for their production |
| abstract | 1503873 5<SP>11</SP>-Amino-3<SP>1</SP>,5<SP>11</SP>-dideoxybutirosin A PARKE DAVIS & CO 15 April 1976 [17 April 1975] 15719/76 Heading C2C Novel 5<SP>11</SP> - amino - 3<SP>1</SP>,5<SP>11</SP> - dideoxybutirosin A and acid addition salts thereof are prepared by reducing a penta-N-protected-5<SP>11</SP>-amino-3<SP>1</SP>-arylthio-3<SP>1</SP>,5<SP>11</SP>-dideoxybutirosin A of the general formula wherein Z is a protective group which is readily removed by reduction and Ar is a group such that ArS is readily removed by reduction, followed optionally by salification. 511 - Amino - penta - N - carbobenzoxy - 3<SP>1</SP>- phenylthio - 3<SP>1</SP>,5<SP>11</SP> - dideoxy - butirosin A is prepared by reacting 2<SP>11</SP>,2<SP>111</SP>,3<SP>11</SP>,6-tetra-O-acetyl- 5<SP>11</SP> - amino - penta - N - carbobenzoxy - 5<SP>11</SP>- deoxybutirosin A with trifluoromethanesulphonic acid anhydride, treating the resulting 3<SP>1</SP>- and 4<SP>1 </SP>- O - trifluoromethanesulphonyl derivatives with thiophenol and sodium hydride to form the 3<SP>1</SP>- and 4<SP>1</SP>-phenylthio derivatives and treating the resulting 3<SP>1</SP>-phenylthio derivative with ammonia. 2<SP>11</SP>,2<SP>111</SP>,3<SP>11</SP>,6 - Tetra - O - acetyl - 5<SP>11</SP> - aminopenta - N - carbobenzoxy - 5<SP>11</SP> - deoxybutirosin A is prepared by treating 5<SP>11</SP>-amino-5<SP>11</SP>-deoxybutirosin A with benzyl chloroformate, reacting the resulting penta-N-carbobenzoxy derivative with 1,1 - dimethoxycyclohexane in the presence of p-toluenesulphonic acid, treating the resulting 3<SP>1</SP>,4<SP>1</SP>-O-cyclohexylidene derivative with acetic anhydride and hydrolysing the resulting 2<SP>11</SP>,2<SP>111</SP>,3<SP>11</SP>,6 - tetra - O - acetyl derivative with water in glacial acetic acid. |
| priorityDate | 1975-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.