http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1502933-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D335-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C223-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C313-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-45 |
| filingDate | 1976-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1502933-A |
| titleOfInvention | Aniline derivatives |
| abstract | 1502933 Aniline derivatives and intermediates thereof UPJOHN CO 5 May 1976 [12 May 1975] 18333/76 Addition to 1479333 Heading C2C The invention comprises certain compounds containing the grouping A-O-Ar-N< and acid addition salts thereof, wherein A is an adamantyl or diamantyl group and Ar is an optionally substituted p-phenylene radical. N - methyl - 4<SP>1</SP> - (1 - adamantyloxy)acetanilide, 41 - (1 - adamantyloxy) - 2<SP>1</SP> - fluoroacetanilide, 4<SP>1</SP> - (1 - diamantyloxy)acetanilide and 4<SP>1</SP> - (1- adamantyloxy) - 3<SP>1</SP> - fluoroacetanilide are obtained by reacting the corresponding amines with acetic anhydride. 1-[4-Adamantyloxy-2- fluorophenyl]pyrrolidine, 1 - [4 - (1 - adamantyloxy) - 2,6 - dimethylphenyl]pyrrolidine, 1 - [4 - (1- diamantyloxy)phenyl]pyrrolidine and N - [4 - (1- adamantyloxy) - 3 - fluorophenyl]pyrrolidine are obtained by reacting the corresponding amines with dibromobutane. 4 - (Adamantyloxy) - 2- methyl - 6 - [(methylthio)methyl]aniline is obtained by reacting the corresponding 6- unsubstituted compound with dimethyl sulphide. 4 - (1 - Adamantyloxy) - 2,6 - dimethylaniline is obtained by desulphurization of the corresponding 6 - methylthiomethyl compound. 4 - (1 - Diamantyloxy)aniline is obtained by brominating diamantane, hydrolysing the 1-bromodiamantane, reacting the 1- diamantanol so produced with p-fluoro-nitrobenzene and reducing the 4-(1-diamantyloxy) nitrobenzene so produced. 4 - (1 - Adamantyloxy) - 3 - fluoroaniline is obtained by nitrating 1,2 - difluorobenzene, reacting the 3,4-difluoronitrobenzene with 1-adamantanol and reducing the 4 - (1 - adamantyloxy) - 3 - fluoronitrobenzene so produced. N - [4 - (1 - adamantyloxy)phenyl]pyrrolidine hydrochloride is obtained by reacting the free base with hydrogen chloride. A pharmaceutical composition comprises one of the above compounds or a salt thereof together with a pharmaceutically acceptable carrier. |
| priorityDate | 1975-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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