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filingDate 1974-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1978-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1502285-A
titleOfInvention Preparation of 4-monohalo-2-pyrazolin-5-ones
abstract 1502285 Production of 4-monohalo-2-pyrazolin-5-ones AGFA-GEVAERT 2 Dec 1975 [11 Dec 1974] 53616/74 Headings C2C and C2P 4 - Monohalo - 2 - pyrazolin - 5 - ones are prepared by the reaction of a tertiary organic phosphite with a 4,4-dihalo-2-pyrazolin-5-one and subsequent hydrolysis of the 4-monohalopyrazole-5-enol phosphate ester formed. The process is particularly suitable for producing products of the general formula in which X is halogen, R<SP>1</SP> is optionally substituted C 1-20 alkyl, optionally substituted aryl, or optionally substituted 5- or 6-membered heterocycle and R<SP>2</SP> is optionally substituted C 1-20 alkyl, C 1-20 alkoxy, amino or substituted amino groups. The reaction is preferably conducted at 10-80‹ C. in an inert solvent such as benzene or acetonitrile using a trialkyl phosphite such as triethyl phosphite. Amongst the examples the compound 1-phenyl-3-(4-chloroanilino) - 4 - chloro - 2 - pyrazolin - 5 - one is prepared. 1 - Phenyl - 3 - (4 - chloroanilino) - 4 - chloro - 5- diethoxy phosphate pyrazole is prepared by reaction of triethyl phosphite and 1-phenyl-3- (4-chloroanilino)-4,4-dichloro-2-pyrazolin-5-one.
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