http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1501321-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D267-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D267-10 |
| filingDate | 1976-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1501321-A |
| titleOfInvention | Morpholine derivatives and processes for the production thereof |
| abstract | 1501321 Polycyclic compounds SUMITOMO CHEMICAL CO Ltd 5 Jan 1976 [6 Jan 1975 4 June 1975] 00224/76 Heading C2C Novel compounds of Formula I wherein R<SP>1</SP> is a hydrogen atom or a C 1 -C 4 alkyl group, R<SP>2</SP> is a hydrogen atom, a C 1 -C 4 alkyl, C 3 -C 5 alkenyl, C 3 -C 5 alkynyl, aryl (C 1 -C 4 )- alkyl, (C 3 -C 6 )cycloalkyl (C 1 -C 4 )alkyl, polyhalo (C 2 -C 4 )alkyl or hydroxy (C 2 -C 4 )alkyl group, A is a straight or branched chain C 2 -C 4 alkylene group, B is -CH 2 -CH 2 -, and C<SP>1</SP> and C<SP>2</SP> are each 1,2-phenylene groups optionally substituted with one or more halogen atoms, C 1 -C 4 alkyl or C 1 -C 4 alkoxy groups, and their non-toxic salts are prepared by one of the following methods: (a) a compound of Formula II is treated with acid and cyclized; (b) a compound of Formula III is reacted with a compound of Formula IV wherein X is a suitable leaving group and R<SP>5</SP> is C 1-4 alkyl, C 3-5 alkenyl, C 3-5 alkynyl, aryl (C 1-4 )- alkyl or C 3-6 cycloalkyl(C 1-4 )alkyl; (c) reacting an epoxide of Formula V with an amine R<SP>6</SP>NHAX, where X is a suitable leaving group, R<SP>6</SP> is H, C 1-4 alkyl, C 3-5 alkenyl, C 3-5 alkynyl, aryl(C 1-4 )alkyl, C 3-6 cycloalkyl- (C 1-4 )alkyl or a polyhalo(C 2-4 )alkyl group, followed by treatment with a base; (d) reducing a compound of Formula VIII wherein R<SP>7</SP> is H, C 1-4 alkyl, C 3-5 alkenyl, C 3-5 alkynyl, aryl C 1-4 alkyl, C 3-6 cycloalkyl(C 1-4 )- alkyl or hydroxy(C 2-4 )alkyl group; A<SP>1</SP> a C 1-3 alkylene group and one of Y<SP>1</SP>, Y<SP>2</SP> is H 2 and the other is O; or (e) treating a compound of Formula IX wherein R<SP>8</SP> is C 1-4 alkyl or aralkyl with an alkyl or aryl formate followed by hydrolysis or by catalytic hydrogenolysis of IX, R<SP>8</SP> = benzyl; (f) catalytic hydrogenation of a compound of Formula X wherein R<SP>9</SP> is R<SP>6</SP> or R<SP>7</SP>; (g) reduction of a comwherein R<SP>10</SP> is alkyl or aryl to the corresponding N-methyl compound; (h) reducing a compound of Formula XII wherein R<SP>11</SP> is R<SP>7</SP> or cycloalkyl or aryl to give a compound of Formula Ih (i) reacting a compound of Formula XIII wherein B<SP>3</SP> is CH 2 -CH 2 , CH=CH, cyclopropylene, CH 2 O, CH 2 S, S or O with R<SP>12</SP>Z where Z is a suitable leaving group and R<SP>12</SP> is as for R<SP>6</SP> or R<SP>7</SP> to give a compound Ii or (j) a compound of Formula Ie and a compound R<SP>11</SP>CHO, are subjected to condensation-reduction to give a compound of Formula Ih above. Pharmaceutical compositions in conventional forms for oral administration having antidepressant activity comprise an above novel compound and a diluent or carrier. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7294637-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9315052-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7411072-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7816375-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004052847-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7132551-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004052847-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7517892-B2 |
| priorityDate | 1975-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 24.