http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1500734-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d4c0ee8a85a8161fe70c3bfefe01a53 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-20 |
| filingDate | 1975-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1500734-A |
| titleOfInvention | Phenoxyalkylamines and their preparation |
| abstract | 1500734 Phenoxyalkylamines ISTITUTO LUSO FARMACO D'ITALIA SRL 5 Feb 1975 [5 Feb 1974 14 Jan 1975] 4926/75 Heading C2C Compounds of the general formula (R 1 =C 1-4 alkyl, monocarbocyclic aryl optionally substituted by one or more halogen atoms or methyl or methoxy groups; R 2 = C 1-4 alkyl, monocarbocyclic aryl optionally substituted by one or more halogen atoms or C 1-4 alkyl or methoxy groups; Alk = C 1-4 alkylene, hydroxyalkylene; R 3 , 4 =H, C 1-4 alkyl, di(C 1-4 alkyl)- amino(C 1-4 alkyl), carbocyclic aryl, C 3-8 cycloalkyl, carbocyclic aryl(C 1-4 alkyl), hydroxyalkyl of up to four carbon atoms in which the OH is separated from N by at least two carbon atoms or NR 3 R 4 =N,N-alkyleneimino containing three to eight carbon atoms optionally bearing one or more substituents selected from methyl, hydroxy, phenyl, p-chlorophenyl, carbamoyl, benzamido and p-fluorobenzyl, N,N- oxo or thioalkyleneimino containing four carbon atoms, or N,N-aza-alkyleneimino containing four to six carbon atoms optionally N-substituted by C 1-4 alkyl or hydroxyalkyl, C 1-4 alkoxy or alkanoyloxy-(C 1-4 alkyl), aryl-(C 1-4 alkyl) or monocarbocyclic aryl, the latter optionally bearing one or more substituents selected from halogen, C 1-4 alkyl and alkoxy, nitro and moncyclic heteroaryl) and their stereoisomers, optical isomers and acid addition salts are prepared by etherifying the corresponding phenol or reacting R 3 R 4 NH with a corresponding halo compound or oxirane, optionally followed by salt formation. These compounds possess, according to the substituents present, local anaesthetic, antiarrhythmic, central nervous system, adrenergic receptor and hypotensive activity, and (in some cases) platelet aggregation inhibiting activity. They may be administered in the form of pharmaceutical preparations containing them in association with a carrier. |
| priorityDate | 1974-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.