http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1500449-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-07 |
| filingDate | 1975-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1500449-A |
| titleOfInvention | Penicillins and cephalosporins |
| abstract | 1500449 Penicillin and cephalosporin derivatives E R SQUIBB & SONS Inc 9 May 1975 19680/75 Heading C2C [Also in Division C3] Novel compounds I (in which A has Formula II or III R 1 is H, 1-8C alkyl, or phenyl-1-8C alkyl; R 2 is H, 1-8C alkyl, phenyl, hydroxyphenyl, thienyl, furyl, or pyridyl; R 3 is H, 1-8C alkyl phenyl-1-8C alkyl, benzhydryl, a salt-forming ion derived from Al, alkali metal, alkaline earth metal, 1-8C alkylamine, phenyl-1-8C alkylamine or N-(1-8C alkyl)piperidine or R 3 is -CH 2 OCOR 4 in which R 4 is 1-8C alkyl, phenyl or phenyl-1-8C alkyl; and X is H, 1-8C alkoxy, alkanoyloxy, 1-8C alkylthio, pyridinium, 5 - methyl - 1,3,4 - thiadiazol - 2 - yl, 5- methyl - 1,3,4 - oxadiazol - 2 - yl, 3 - methyl- 1,2,4 - thiadiazol - 5 - yl, 4 - methyl - tetrazol- 5 - yl, or N - oxido - pyrid - 2 - ylthio) are prepared by conventional acylation of the appro - priate 6-aminopenicillanic acid or 7-aminocephem derivatives. Compounds IV may be prepared by reaction of a compound V NC-CH 2 R 2 with hydroxylamine to give a compound VI, HON = C(NH 2 )CH 2 R 2 ; reaction of the compound VI with Cl 3 CCOCl to give a compound VII reaction of the compound VII with NaOH to give the compound VIII and, where R 1 is H, treatment of the compound VIII with butyl lithium and CO 2 to give the compound IV where R 1 is H; or, where R 1 is other than H, treatment of the compound VIII with a compound IX R 1 Hal (Hal is halogen) followed by treatment with butyllithium and CO 2 . Alternatively the compounds IV may be prepared by reaction of a compound X with hydroxylamine to give a compound XI HON = C(NH 2 )-CH(R 2 )-COOAlkyl; reaction of the compound X with Cl 3 CCOCl to give a compound XII and reaction of the compound XII with NaOH followed where necessary by reaction with a compound IX. Antibacterial compositions comprise a compound I together with a suitable carrier and/or diluent. |
| priorityDate | 1975-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 34.