http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1499553-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30432c021c19453629a3b69ce104640e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-23 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-23 |
| filingDate | 1975-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1499553-A |
| titleOfInvention | Processes for producing butirosin derivatives and intermediate compounds useful in the processes |
| abstract | 1499553 Butirosin A derivatives PARKE DAVIS & CO 5 Sept 1975 [6 Sept 1974] 36764/75 Heading C2C O - 2,6 - Diamino - 2,3,4,6- tetradeoxy- α - D - erythro - hexopyranosyl - (1#4) - O- [5 - amino - 5 - deoxy - # - D - xylofuranosyl- (1#5) - N<SP>1</SP> - [(5) - 4 - amino - 2 - hydroxy- 1 - oxobutyl] - 2 - deoxystreptamine (i.e. 5<SP>11</SP> - amino - 3<SP>1</SP>,4<SP>1</SP>,5<SP>11</SP> - trideoxybutirosin A) and acid addition salts thereof are prepared by catalytic hydrogenation of a 5<SP>11</SP>-amino-penta- N - arylmethoxycarbonyl - 3<SP>1</SP>,4<SP>1</SP>,5<SP>11</SP> - trideoxybutirosin - 31,41 - ene A and isolation of the product in free base or acid addition salt form. 5<SP>11</SP> - Amino - penta - N - arylmethoxycarbonyl- 3<SP>1</SP>,4<SP>1</SP>,5<SP>11</SP> - trideoxybutirosin - 3<SP>1</SP>,4<SP>1</SP> - enes A are prepared by reacting 5-O-(5-amino-5-deoxy- D - xylofuranosyl) - N<SP>1</SP> - (4 - amino - 2 - hydroxybutyrl) - 4 - O - (2,6 - diamino - 2,6 - dideoxy- D - glucopyranosyl) - 2 - deoxystreptamine (i.e. 511 - amino - 511 - deoxybutirosin A) with an arylmethyl chloroformate, treating the resulting 5<SP>11</SP> - amino - penta - N - arylmethoxycarbonyl - 5<SP>11</SP> - deoxybutirosin A with a 1,1- dimethoxy-C 5-8 - cycloalkane and p - toluenesulphonic acid, acylating the resulting 5<SP>11</SP>- amino - penta - N - arylmethoxycarbonyl - 3<SP>1</SP>,4<SP>1</SP>- O C 5-8 - cycloalkylidene - 511 - deoxybutirosin A, hydrolysing the resulting 2<SP>11</SP>,2<SP>111</SP>,3<SP>11</SP>,6-tetra-O- acyl - 5<SP>11</SP> - amino - penta - N - arylmethoxycarbonyl - 3<SP>1</SP>,4<SP>1</SP> - O - C 5-8 - cycloalkylidene - 5<SP>11</SP>- deoxybutirosin A, reacting the resulting novel 2<SP>11</SP>,2<SP>111</SP>,3<SP>11</SP>,6 - tetra - O - acyl - 5<SP>11</SP> - aminopenta - N - arylmethoxycarbonyl - 5<SP>11</SP> - deoxybutirosin A with methanesulphonyl chloride, treating the resulting 2<SP>11</SP>,2<SP>111</SP>,3<SP>11</SP>,6-tetra-O-acyl- 5<SP>11</SP> - amino - penta - N - arylmethoxycarbonyl - 5<SP>11</SP> - deoxy - 31,41 - di - 0 - methanesulphonylbutirosin A with zinc and sodium iodide and treating the resulting 2<SP>11</SP>,2<SP>111</SP>,3<SP>11</SP>,6- tetra - O - acyl - 511 - amino - penta - N - arylmethoxycarbonyl - 3<SP>1</SP>,4<SP>1</SP>,5<SP>11</SP> - trideoxybutirosin- 3<SP>1</SP>,4<SP>1</SP>-ene A with ammonia in methanol. Reference has been directed by the Comptroller to Specification 1,453,207. |
| priorityDate | 1974-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.