http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1498633-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e77f06144be4708a6ae75bd9fee56a4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 |
| filingDate | 1975-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1498633-A |
| titleOfInvention | 2-phenyl-piperazines and 4-phenyl-hexahydro pyrimidines |
| abstract | 1498633 2-Phenyl-piperazine and 4-phenylhexahydropyrimidine derivatives AKZO NV 28 Jan 1975 [9 Feb 1974] 39732/76 Divided out of 1498632 Heading C2C Novel compounds III and salts thereof in which R 1 and R 2 are H, OH, Hal, C 1-4 alkyl, C 1-4 alkoxy or CF 3 ; R 3 is H, C 1-6 alkyl, C 7-10 aralkyl or amino C 1-6 alkyl in which the amino group is di-C 1-6 alkylated or forms part of a heterocyclic 5- or 6-membered ring; X is OH, Hal, acyloxy or etherified hydroxy; and m = 1 and n = 2 or m = 2 and n = 1; are prepared by reacting a compound VII or a salt thereof in which Y has the same meaning as X except Hal, with (i) Cl-CH 2 COOEt or (COOEt) 2 and reducing the ketone obtained to form compounds III (m = 2, n = 1), (ii) formaldehyde or ClCOOEt and reducing the ketone obtained to form compounds III (m = 1, n=2) or (iii) CH 2 Cl 2 to form compounds III (m = 1, n=2). Compounds III (X = Hal) and (X = acyloxy) are also prepared by halogenating or acylating the corresponding hydroxy compound. Compounds III (m = 2, n = 1) are also prepared by reacting a compound IV or a salt thereof with a compound V or a salt thereof. Compounds IV are prepared by reacting a compound VI or a salt thereof with a dihaloethane, a 1- hydroxy-2-haloethane or ethylene oxide and halogenating any free hydroxy group. Compounds VI are prepared by reacting styrene oxide with an amine R 3 NH 2 . Compounds VII are prepared by reacting a compound VIII or a salt thereof with a compound IX or a salt thereof. Compounds VIII are prepared by halogenating the corresponding α-hydroxy compound. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2138016-A |
| priorityDate | 1974-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.