http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1498629-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61 |
| filingDate | 1974-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1498629-A |
| titleOfInvention | Pyridylalkyl derivatives of urea and thiourea |
| abstract | 1498629 Pyridylalkyl derivatives of urea and thiourea UPJOHN CO 23 Dec 1974 [26 Dec 1973] 55422/74 Heading C2C Novel compounds I and II (R 1 and R 2 are H, halo, 1-6C hydrocarbyl, alkoxy, alkylthio, NO 2 , amino, alkylamino, dialkylamino, acylamino or trihalomethyl; R 3 and R 4 are H, hydrocarbyl or aryl optionally substituted by halo, NO 2 , 1-4C alkoxy, or hydrocarbyl ; R 5 and R 6 are H, halo, hydrocarbyl, halo - hydrocarbyl, NO 2 , CN, amino, acylamino, alkylamino, dialkylamino, alkylthio, alkoxy, arylthio or aryloxy; X is O or S and n is 1 or 2, with the provisos that, in Formula II, (1) when R 1 , R 2 , R 4 , R 5 and R 6 are H and X is S that R 3 is H, cycloalkyl, aryl, aralkyl or aryl substituted by halo, NO 2 , 1-4C alkoxy or hydrocarbyl; (2) when R 1 and R 2 are H or halo: R 4 , R 5 and R 6 are H and X is O, that R 3 is 1-4C alkyl, cycloalkyl, aryl, aralkyl, or aryl substituted by halo, NO 2 , 1-4C alkoxy or hydrocarbyl; and (3) when R 1 , R 2 , R 3 , R 4 and R 6 are H, X is O and n is 1, that R 5 is not CF 3 , NO 2 , CN or alkylthio) and pharmaceutically acceptable salts thereof are prepared by known methods, e.g. by reaction of a compound IV with a compound V or by reaction of a compound VIII with a compound IX followed where necessary by N-oxidation. Pharmaceutical compositions comprise a compound I or II together with the usual carriers and are useful in increasing the production of endogenous prostaglandins. |
| priorityDate | 1973-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.