http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1498048-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5929f2d6f4dba84be8dd3a8ba633db12 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-23 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-103 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-23 |
| filingDate | 1975-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1498048-A |
| titleOfInvention | Decapeptide amides |
| abstract | 1498048 Decapeptide amides TAKEDA YAKUHIN KOGYO KK 7 March 1975 [8 March 1974] 9539/75 Heading C3H Peptides of the formula wherein R 1 is Tyr or Phe, R 2 is D-Nle, D-Nva, D-Abu, D-Phe, D-Ser, D-Thr or D-Met, R 3 is Leu, Ile or Nle, may be prepared by a method which comprises the condensation of (A) L- pyroglutamic acid or a protected L-glutamic acid, or a peptide component which has an L- pyroglutamic acid residue or a protected L- glutamic acid residue as its N-terminus with (B) an amine component, the two components, taken together, corresponding to (I), wherein any groups not taking part in the condensation are optionally protected; converting the L- glutamyl residue to L-pyroglutamyl with acid or base, if necessary; and removing any protective groups, to yield the peptide (I). The peptides may be obtained by solid-phase synthesis. The following compounds are prepared The intermediates isolated are: DECAPEPTIDES: H - (Pyr)Glu - His(Tos) - Trp - Ser(Bzl)- Tyr(Bzl) - D - Nle - Leu - Arg - Pro - Glyresin and NH 2 ; H - (Pyr)Glu - His - Trp - Ser- Phe - D - NVa - Len - Arg(NO 2 ) - Pro - Gly- NH 2 . PENTAPEPTIDE: Z - D - Nva - Leu- Arg(NO 2 ) - Pro - Gly - NH 2 . Pharmaceutical compositions, which induce ovulation, comprise peptides (I) together with a non-toxic carrier or diluent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0047079-A1 |
| priorityDate | 1974-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.