http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1497634-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3bfedd8ba4800708cecfd357707f8f67 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0825 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-097 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 |
| filingDate | 1976-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1497634-A |
| titleOfInvention | Process for the preparation of thyrotropin-releasing hormone |
| abstract | 1497634 TRH AKADEMIE DER WISSENSCHAFTEN DER DDR 18 March 1976 [24 March 1975] 10910/76 Heading C3H A process for the preparation of L-pyroglutamyl . L - histidyl - L - prolinamide wherein an activated ester of di(t-butyloxycarbonyl)-L- histidine is reacted with L-prolineamide in a solvent at a temperature of 0 to 50‹ C., the L - histidyl - L - prolineamide thus formed, after removal of the protective groups, is isolated as the hydrochloride, and the said hydrochloride is then reacted with an activated ester of L - pyroglutamic acid. The p - nitrophenyl ester of di(t-butyloxycarbonyl)-L-histidine is preferred with dimethylformamide as the preferred solvent. The di(t-butyloxycarbonyl)-L- histidyl-L-prolineamide, after removal of solvent may be treated with hydrochloric acid/glacial acetic acid, and the L-histidyl-L-prolinamide hydrochloride may be isolated by trituration preferably with diethyl ether, followed by reprecipitation, perferably by dissolution in methanol, and addition of diethyl ether. The L-pyroglutamic acid is preferably as the pentachlorophenyl, 2,4,5-trichlorophenyl or o-nitrophenyl ester with the reaction preferably being effected in dimethylformamide, most preferably in the presence of base, especially triethylamine. In the Example; peptides prepared are: TRIPEPTIDE: H-Pyroglu-Hio-Pro-NH 2 DIPEPTIDES: Boc-His(Boc)-Pro-NH 2 ; H-His-Pro-NH 2 |
| priorityDate | 1975-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.