| abstract |
1496627 Araliphatic dihalogen compounds and their preparation MERCK PATENT GmbH 28 June 1976 [28 June 1975] 26881/76 Heading C2C Araliphatic dihalogen compounds of the formula wherein R<SP>1</SP> and R<SP>2</SP>, which may be the same or different, are F, Cl or Br, Q is Y is COOH, COOR<SP>3</SP>, CH 2 OH or CH 2 OAc, n is 0 or 1, R<SP>3</SP> is alkyl or optionally substituted aryl with up to 8 carbons in each case, and Ac is acyl with 1 to 8 carbon atoms, and physiologically acceptable salts thereof, may be obtained (a) by converting the X radical in a compound of the formula wherein Z is the group and X is a radical which can be converted into the -Q-Y group, into the -Q-Y group, (b) by reacting a compound of the formula or a salt thereof, with a compound of the formula or a salt thereof, wherein one of the groups Q<SP>1</SP> and Q<SP>2</SP> is OH and the other is L, L is hal, OH or a functionally modified hydroxyl group, and hal is Cl, Br or I, or (c) by diazotizing a compound of the formula wherein R<SP>4</SP> is NH 2 or R<SP>1</SP> and R<SP>5</SP> is NH 2 or, if R<SP>4</SP> is NH 2 , also R<SP>2</SP>, and treating the resulting diazonium salt with a halogenating agent. The resulting compounds of Formula (I) may be treated by conventional methods, a number of which are specified, to convert one or more of the Q and/or Y radicals therein into one or more different Q and/or Y radicals. The products possess therapeutic (anti-inflammatory) properties and may be formulated and applied in a known manner. |